The Effects of Different Ventilator Strategies on Inflammation and Injury in Normal Lungs
Stopped early · Not applicable
Conditions studied: Acute Respiratory Distress Syndrome
In brief
This research is being done to determine if there is a way the investigators can improve the techniques that they use to assist patients with their breathing during surgery. The majority of surgeries require patients to concurrently undergo general anesthesia. This usually includes a breathing tube and a machine that breathes for the patient during the duration of the surgery. The doctors would like to investigate the effects of this type of anesthesia to healthy adult patients and whether they can improve the way they give general anesthesia to patients. The investigators plan to ask approximately 200 patients to participate. If the patients decide to participate in the study,some additions will be made to the standard anesthetic care they receive. The patients will additionally be monitored for adequate oxygenation in their blood as well as level of inflammation in their blood and lungs. The patients' breathing tube will be bathed with warm normal saline and suctioned twice during the operation. When these procedures are done the patients will be asleep and not be aware of what is happening.
Key facts
- Study ID
- NCT01003730
- Run by
- University of Medicine and Dentistry of New Jersey
- People needed
- 1
- Starts
- 2009-03-01
- Expected to finish
- 2010-03-01
- Last updated by the study team
- 2015-05-05
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Elective surgery under general anesthesia expected to take 4 hours or more positioned supine for surgery
You may not qualify if…
- Subjects who have HIV or who have had Radiation or chemotherapy for cancer
- Subjects undergoing surgery on chest or lings
- Subjects who have obstructive sleep apnea (OSA), asthma, tuberculosis, chronic obstructive pulmonary disease
Where it is running
- UMDNJ/University Hospital — Newark, New Jersey, United States
Full record on ClinicalTrials.gov
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