Safety And Tolerability Study Of RN6G In Subjects With Advanced Dry, Age-Related Macular Degeneration Including Geographic Atrophy

Completed · Phase 1 · Has a placebo group

Conditions studied: Age-Related Maculopathy, Age-Related Maculopathies, Eye Diseases, Retinal Degeneration, Macular Degeneration

In brief

The purpose of this study is to determine the safety and tolerability of multiple doses of RN6G in subjects with advanced dry, age-related macular degeneration including geographic atrophy.

Key facts

Study ID

NCT01003691

Run by

Pfizer

People needed

24

Starts

2010-08-05

Expected to finish

2013-04-19

Last updated by the study team

2022-05-12

Who can join

Age: 60 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Be of non-child bearing potential
• Diagnosis of dry AMD including uni- or multi-focal geographic atrophy without foveal involvement
• BCVA of 20/50 or better in the study eye

You may not qualify if…

• Evidence of ocular disease other than advanced AMD or GA in the study eye
• History or diagnosis of exudative (wet) AMD, with subretinal or choroidal neovascular lesions in the study eye
• Presence of disease or condition that might compromise the cardiovascular, hematological, renal, hepatic, pulmonary, endocrine, central nervous immune, or gastrointestinal system
• Requires ocular or systemic medications that are known to be toxic to the lens, retina or optic nerve

Where it is running

• Retinal Diagnostic Center — Campbell, California, United States
• American Institute of Research (Administrative Only) — Los Gatos, California, United States
• Neurology Center Rai Kumar — San Jose, California, United States
• Harmeet Sachdev, MD, FAAN — San Jose, California, United States
• Santa Clara Drug — San Jose, California, United States
• Retina Associates of Florida, PA — Tampa, Florida, United States
• Hoye's Pharmacy — Tampa, Florida, United States
• Ranjit K. Sethi, MD, PC — Augusta, Georgia, United States
• Clinical Specialists, LLC — Augusta, Georgia, United States
• Southeast Retina Center, PC — Augusta, Georgia, United States
• University of Rochester Medical Center — Rochester, New York, United States
• University of Rochester — Rochester, New York, United States
• Hawthorne Pharmacy — West Columbia, South Carolina, United States
• Jay Markowitz and Associates — West Columbia, South Carolina, United States
• Palmetto Retina Center, LLC — West Columbia, South Carolina, United States
• South Carolina Neurological — West Columbia, South Carolina, United States
• National Central Pharmacy — Abilene, Texas, United States
• Abilene Surgery Center — Abilene, Texas, United States
• Heart and Vascular Institute — Abilene, Texas, United States
• Retina Research Institute of Texas — Abilene, Texas, United States
• Brian B. Berger, MD, PA — Austin, Texas, United States
• Retina Research Center, PLLC — Austin, Texas, United States
• Sleep Medicine Consultants — Austin, Texas, United States
• Specialty Compounding — Cedar Park, Texas, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.