Natural History of Levodopa-Induced Dyskinesia (LID)
Withdrawn before enrolling
Conditions studied: Parkinson's Disease
In brief
Levodopa is the main drug treatment for Parkinson's disease. Levodopa can cause unwanted and uncontrolled movements called dyskinesias (LID). The severity of these movements can range from subtle to extremely debilitating. These movements may or may not interfere with normal activities such as putting on a coat or brushing ones teeth. Current estimates of the occurrence rate of LID range from 12 % to 100% after one year of levodopa treatment. These estimates used reporting mechanisms such as self-report and doctor-reported. These reporting mechanisms are not reliable. We will use an objective measure of dyskinesia in the first 5 years of treatment for Parkinson's disease. The purpose of this protocol is to use an objective measure to estimate dyskinesia onset.
Key facts
- Study ID
- NCT01003002
- Run by
- Oregon Health and Science University
- People needed
- 0
- Starts
- 2010-12-01
- Expected to finish
- 2020-12-01
- Last updated by the study team
- 2016-04-06
Who can join
Age: 21 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of Parkinson's disease
- At least 21 years of age
- Levodopa treatment that will be orally initiated no more than 1 month after the screening visit for the study.
You may not qualify if…
- Unable to stand for 1 minute intervals
- Sensory deficits in the feet
- Significant cognitive impairment
- Unstable medical or psychiatric conditions (including hallucinations)
- History of dopamine receptor blocking medications (Haldol, Orap, Zyprexa)
Where it is running
- Oregon Health & Science University — Portland, Oregon, United States
Full record on ClinicalTrials.gov
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