Treatment of Traumatic Brain Injury (TBI)-Related Attention Deficits
Stopped early · Phase 3 · Has a placebo group
Conditions studied: Traumatic Brain Injury, Attention Deficit Disorder
In brief
The purpose of this research study is to evaluate whether Vyvanse, a psychostimulant, can help with attention deficits due to traumatic brain injury (TBI). Vyvanse is currently approved for the treatment of Attention-Deficit/Hyperactivity (ADHD). The exact effects this drug may have on attention deficits caused by TBI are not known, but we expect that Vyvanse will be of some help in treating those types of problems as well. The study will utilize functional magnetic resonance imaging (fMRI) methods, as well as neurobehavioral measures, to elucidate neural mechanisms of response.
Key facts
- Study ID
- NCT01000064
- Run by
- Vanderbilt University
- People needed
- 22
- Starts
- 2009-10-01
- Expected to finish
- 2015-05-01
- Last updated by the study team
- 2017-05-19
Who can join
Age: 16 and older, up to 45. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Males and females, ages 16 to 45
- Closed head injury rated as moderate/severe (based on Glasgow Coma Scale rating, estimated posttraumatic amnesia, etc.)
- Sustained 6 to 36 months earlier, and considered to be neurologically stable
- Persistent (> 6 months) problems with focused or sustained attention (+1 SD or worse on Inattention component of ADHD self ratings) corroborated by professional staff (nurses, therapists, etc.) or caregivers. Problems with attention/concentration rated as among most prominent cognitive changes.
- Accompanying features may include diminished arousal/speed/stamina and/or disinhibited symptoms
You may not qualify if…
- Penetrating head injury
- Pre-injury history of diagnosed ADHD
- Other psychiatric conditions such as mania or psychosis. Current posttraumatic stress disorder (PTSD) symptoms may be present but not so severe as to require pharmacologic treatment.
- Lifetime history of psychostimulant abuse or dependence. Other (non-psychostimulant) substance abuse within the past 6 months. Total lifetime drug use will not exceed 5 times each for substances such as amphetamine, meth-amphetamine, or cocaine.
- Prior treatment with psychostimulant(s)
- Tics or other contraindications for psychostimulant use including arteriosclerosis, cardiovascular disease, uncontrolled hypertension or hyperthyroidism, glaucoma, agitation, use of MAO inhibitor within 6 weeks
- Current treatment with other psychotropic medication(s) within the past 6 weeks
- Estimated IQ < 80
- Sensory and/or motor impairment(s) seriously limiting testing options
- Other neurological conditions including epilepsy, degenerative disorders, brain tumor, or stroke.
- Physical conditions affecting arousal, activity level or stamina, including uncontrolled thyroid dysfunction, anemia, autoimmune or metabolic disorders, untreated moderate/severe sleep apnea, etc.
- Persons for whom MRI scanning is contraindicated, including weight greater than 275 pounds (due to scanner table limitations), severe claustrophobia, implanted electronic medical devices (e.g. pacemaker, cochlear or other inner ear implant, deep brain stimulator), metallic foreign object in eye or rest of the body, history of sheet metal work, aneurysm clips, non-removable metallic piercings, and dental prosthetics.
Where it is running
- Vanderbilt University — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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