Surveillance of Influenza Virus Shedding and Immunologic Response in Immunocompromised Children and Young Adults
Completed
Conditions studied: Influenza Virus
In brief
Influenza virus infections are a major cause of morbidity and mortality. The limited existing knowledge about the impact of influenza in immunocompromised patients suggests that they are at increased risk of influenza virus acquisition, of developing complications and of prolonged illness and viral shedding. However, some other data about the effect of antiviral agents on the infection course, and risk of resistance in immunocompromised children are lacking. The emergence of the pandemic H1N1 swine-origin influenza A virus has generated an additional need to study the epidemiology, clinical course and outcome of influenza infections in immunocompromised children. This study proposed to conduct a prospective observational clinical study to answer these questions.
Key facts
- Study ID
- NCT00998803
- Run by
- St. Jude Children's Research Hospital
- People needed
- 9
- Starts
- 2009-10-01
- Expected to finish
- 2012-06-01
- Last updated by the study team
- 2012-11-01
Who can join
Age: any, up to 21. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age <= 21 years of age at the time of entry into the study.
- Body weight of 13 kg or greater
- An immunosuppressed state due to cancer, sickle cell disease, HIV, or receipt of stem cell transplant
- Presentation with acute respiratory illness defined as recent onset of rhinorrhea, nasal and sinus congestion, pharyngitis, coryza, sinusitis, otitis media, dyspnea or shortness of breath, cough and/or a new radiographic pulmonary infiltrates.
- Proven influenza virus infection by virological testing of respiratory specimens using Polymerase Chain reaction (PCR) assay, direct antigen detection assay, or viral culture.
You may not qualify if…
- Inability or unwillingness of research participant or legal guardian to give written informed consent.
Where it is running
- St . Jude Children's Research Hospital — Memphis, Tennessee, United States
Full record on ClinicalTrials.gov
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