Study to Evaluate the Effect of a Very Low Carbohydrate Diet on Gastroesophageal Reflux Disease
Completed · Not applicable
Conditions studied: Gastroesophageal Reflux Disease, Overweight, Acid Reflux Disease
In brief
The purpose of this research study is to learn if a very low carbohydrate (sugar) diet or traditional low fat diet is able to reduce symptoms related to gastroesophageal reflux disease (GERD) in people who are overweight. Patients with GERD may experience all or some of the following symptoms: stomach acid or partially digested food re-entering the esophagus (which is sometimes referred to as heartburn or regurgitation) and belching. In this study, the investigators also hope to find out if acid in the esophagus is reduced more by a low carbohydrate diet than a low fat diet.
Key facts
- Study ID
- NCT00998244
- Run by
- University of North Carolina, Chapel Hill
- People needed
- 40
- Starts
- 2009-09-01
- Expected to finish
- 2011-12-01
- Last updated by the study team
- 2012-01-09
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18 to 70 years old
- BMI between 30 kg/m2 and 45 kg/m2
You may not qualify if…
- Known history of Barrett's esophagus or esophageal adenocarcinoma
- Previous surgical anti-reflux procedure
- Previous weight loss surgery, including gastric bypass
- Diabetes
- Pregnancy
- Heart Disease
- Unwillingness to discontinue use of proton pump inhibitors (PPI's) or H2-receptor antagonists per study protocol
Where it is running
- The University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States
Full record on ClinicalTrials.gov
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