Effect of Ranolazine on Arrhythmias and Microvolt T- Wave Alternans (MVTWA) Patients With LV Dysfunction
Completed · Phase 3 · Has a placebo group
Conditions studied: Sudden Cardiac Death, Ventricular Arrythmias
In brief
The purpose this investigation is to more thoroughly investigate the effects of ranolazine on arrhythmias and microvolt t-wave alternans in patients who have an automatic implantable cardioverter defibrillator (AICD) implanted either prophylactically to prevent sudden cardiac death, as well as in patients who may have had a clinically significant arrhythmic event prompting the insertion of the automatic implantable cardioverter defibrillator. It is anticipated this study will provide valuable new insight into the potential use of ranolazine to treat arrhythmias in higher risk patients.
Key facts
- Study ID
- NCT00998218
- Run by
- Aspirus Heart and Vascular Institute-Research and Education
- People needed
- 7
- Starts
- 2009-09-01
- Expected to finish
- 2010-12-01
- Last updated by the study team
- 2012-02-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Implant of AICD for the prevention of sudden cardiac death Implant of AICD for the prevention of sudden cardiac death
You may not qualify if…
- Any anti-arrhythmic agent (other than beta-blockers)
- History of or intolerance to ranolazine during the run in.
- History of severe constipation defined as requiring laxatives more than 5 times a week in order to have a bowel movement.
- Because of a weak inhibitory effect of ranolazine of the cytochrome p450, CYP 3A4, certain drugs metabolized by that system could accumulate. Although clinically significant interactions of ranolazine with these agents has not been demonstrated, patients on maximum doses of simvastatin, or patients on verapamil or diltiazem will be excluded.
Where it is running
- Aspirus Wausau Hospital — Wausau, Wisconsin, United States
Full record on ClinicalTrials.gov
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