Early Detection of Diastolic Dysfunction and the Role of Lifestyle Measures in Its Treatment
Completed · Not applicable
Conditions studied: Diastolic Dysfunction
In brief
The project aims to investigate the effect of a regular exercise for 6 months on diastolic parameters in patients who present with shortness of breath and who have evidence of early diastolic dysfunction on echocardiography. Patients will be enrolled from the VA General Medicine and Cardiology Clinics, and will be screened for diastolic dysfunction. Once enrolled, they will be on an exercise regimen that involves aerobic exercise for 30-45 minutes five times a week at home. The participants will have an initial supervised exercise session with the VA Cardiac Rehabilitation team, and will have either every other week or monthly supervised sessions at the VA Cardiac Rehabilitation Center to monitor their progress. Clinical, biometric, laboratory and echocardiographic parameters will be obtained before and after the 6 month period.
Key facts
- Study ID
- NCT00998114
- Run by
- University of Missouri-Columbia
- People needed
- 9
- Starts
- 2008-06-01
- Expected to finish
- 2011-05-01
- Last updated by the study team
- 2016-10-05
Who can join
Age: 40 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with dyspnea/shortness of breath
- Age 40-65 years of age
- Sedentary lifestyle (<150 minutes of exercise/week)
- Echocardiographic evidence of early diastolic dysfunction: mitral E/A <0.9, OR resting E/E' between 8-15 cm/s, OR post-exercise E/E' >13 cm/s.
You may not qualify if…
- Age <40 years or >65 years
- Coronary Artery Disease by angiography or evidence of ischemia on a stress test
- Systolic Dysfunction (LV Ejection fraction <50%)
- Congestive Heart Failure Functional Class III or IV
- Moderate to severe COPD (FEV <80% predicted)
- Moderate to severe valvular heart disease, except tricuspid regurgitation
- Inability to get heart rate >/= 85% of maximum predicted heart rate
- Uncontrolled hypertension (systolic BP>140mmHg, diastolic BP>90mmHg) despite medical therapy
- On echocardiogram, RV systolic pressure >60mmHg that suggests severe pulmonary hypertension
- On echocardiogram, left atrial size> 6.5 cm or left atrial volume > 35 ml/BSA
Where it is running
- Harry S Truman Veterans Administration Hospital — Columbia, Missouri, United States
Full record on ClinicalTrials.gov
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