Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins

Completed · Not applicable

Conditions studied: Hyperglycemia

In brief

Anesthetic preconditioning (APC, a brief exposure to an anesthetic gas) has become an area of intense research interest because of its ability to protect tissue and organs from injury resulting from a cessation of blood flow and then a re-establishment of flow. The blood vessel lining plays a key role in this injury. This research will examine, in human volunteers, several important modifiers of APC in human blood vessels: high blood sugar, vitamin C, and statin drugs. Thus, the proposed studies will advance the investigators' understanding of mechanisms of this injury in humans and explore important modifiers of APC protection from injury.

Key facts

Study ID

NCT00995670

Run by

US Department of Veterans Affairs

People needed

59

Starts

2010-03-01

Expected to finish

2013-09-01

Last updated by the study team

2015-03-17

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Young, healthy volunteers, 18-35 yr of age;
• Females will be studied at the same phase of their estrous cycle in each protocol.

You may not qualify if…

• Beta-blocker therapy or any medication that might interfere with vascular responses;
• Pregnant or lactating women;
• Substance abusers;
• Smokers;
• Anyone with cardiovascular, renal, or other systemic disease including hypertension and/or diabetes;
• Also excluded are volunteers with family history of malignant hyperthermia, or significant gastro-esophageal reflux.

Where it is running

• Zablocki VA Medical Center, Milwaukee — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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