Following Lipectomy to Understand Adipose Tissue Re-accumulation
Completed · Not applicable
Conditions studied: Menopause, Pre-menopause
In brief
The typical female pattern of accumulating fat in the hips and thighs has long been thought to confer less risk for disease than the typical male abdominal fat pattern. However, leg fat may not simply be benign with respect to disease risk, but may in fact protect against cardiovascular disease risk. Although the mechanism for this is unknown, the investigators hypothesize that removing a portion of this important fat depot (via liposuction) could increase disease risk. Such unfavorable results may or may not be transient depending on an individual's ability to defend their fat mass. Because sex hormones appear to play a role in regional fat accumulation, the investigators hypothesize that estrogen-deficient postmenopausal women may have an augmented abdominal fat accumulation and an attenuated hip and thigh re-accumulation compared to premenopausal women following lipectomy and compared to non-surgical controls. As a result, the increased abdominal fat accumulation may worsen disease risk in postmenopausal women. Menopause-related differences in fat storage at baseline are also expected to determine the degree to which lipectomy alters disease risk and the propensity for AT re-accumulation.
Key facts
- Study ID
- NCT00995631
- Run by
- University of Colorado, Denver
- People needed
- 53
- Starts
- 2008-01-01
- Expected to finish
- 2014-12-01
- Last updated by the study team
- 2017-01-11
Who can join
Age: 35 and older, up to 60. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- post-menopausal (no menses for 12mo or oophorectomy w/ follicle-stimulating hormone (FSH)>30 IU/L) OR- pre-menopausal (regular menses 28+/-3d)
- BMI >20 and <30 kg/m2)
- weight stable (+/- 2kg in past 2mo)
- non-smoking
- no use of hormone therapies or oral contraceptives
- actively seeking liposuction of the hips and thighs
- good femoral lipectomy candidates as determined by cosmetic surgeon
You may not qualify if…
- severe hypertriglyceridemia (>400 mg/dL)
- medications known to affect lipid metabolism
- elevated resting blood pressure (Systolic >140 mm Hg,Diastolic >90 mm Hg)
- history of lipectomy or gastric bypass surgery
- body dysmorphic disorder
- pregnant, lactating or intention of becoming pregnant
- indication of high surgical risk (e.g., abnormal resting ECG, history of thromboembolism, valvular heart disease)
Where it is running
- University of Colorado Anschutz Medical Campus — Aurora, Colorado, United States
Full record on ClinicalTrials.gov
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