Mechanisms Defending Fat Mass in Humans After Lipectomy

Completed · Not applicable

Conditions studied: Disproportionate Shape, Expanded Fat Pads

In brief

Liposuction surgery is common, yet animal and limited human data suggest that fat returns when removed. This study was designed as a 1-year randomized-controlled trial of suction lipectomy versus no intervention to determine if adipose tissue is defended, and if so to determine the anatomic pattern of redistribution.

Key facts

Study ID

NCT00993213

Run by

University of Colorado, Denver

People needed

32

Starts

2004-04-01

Expected to finish

2008-11-01

Last updated by the study team

2016-12-06

Who can join

Age: 18 and older, up to 50. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Eligible premenopausal women between the ages of 18-50 years;
• BMI of 22-27 kg/m2 at the subjects maximum body weight;
• Weight stable for at least 3 months (defined as a <5-7% change from the maximum weight over 3-6 months);
• Non-smokers.

You may not qualify if…

• Any history of glucose intolerance, dyslipidemia, liver, kidney and cardiac disease, hypertension, cancer or any other chronic debilitating disorder that might have interfered with a 'normal' lifestyle, e.g. nutrition, physical activity;
• Thyroid hormone replacement with abnormal thyroid stimulating hormone (TSH) results;
• Use of oral contraceptives if the subject did/could not remain on therapy throughout study participation.
• Reduced-obese, defined as a history of:
• obesity and weight loss >10% of maximum body weight, or
• liposuction or gastric bypass surgery;
• Evidence of body dysmorphic disorder;
• Taking sex steroids, glucocorticoids, or medications affecting carbohydrate and lipid metabolism;
• Hematocrit, hemoglobin, white blood cell count (WBC), platelet count, liver or renal function tests out of the normal range;
• Fasting plasma glucose >110 mg/dL;
• Triglycerides >200 mg/dL;
• High density lipoprotein (HDL) cholesterol <35 mg/dL;
• Low density lipoprotein (LDL) cholesterol >160 mg/dL;
• Proteinuria;
• Blood pressure >140/90 mm/Hg;
• Electrocardiogram abnormalities;
• History of claustrophobia;
• Placement of metal implants*
• History of internal metal fragments*
• Were evaluated by the radiologist prior to study determination*

Where it is running

• University of Colorado Denver — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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