Study on the Development of Opioid Induced Hyperalgesia (OIH) After Exposure to Alfentanil

Completed · Not applicable

Conditions studied: Hyperalgesia

In brief

The purpose of this study was to follow a person's response to experimental pain after multiple consecutive exposures to alfentanil or diphenhydramine to see if the person can tolerate the pain more, less, or the same at the end of the study.

Key facts

Study ID

NCT00991809

Run by

Johns Hopkins University

People needed

22

Starts

2009-02-01

Expected to finish

2010-05-01

Last updated by the study team

2017-10-06

Who can join

Age: 18 and older, up to 55. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Age 18-55
• No active medical conditions
• BMI between 20-30
• Able and willing to perform/tolerate pain procedures
• Able to communicate in English

You may not qualify if…

• Lifetime substance use disorder, except for alcohol abuse/dependence in remission
• Use of opiates in last 3 months
• Ongoing marijuana use
• Acute or chronic pain
• Neurologic or psychiatric condition known to influence cold pressor testing (peripheral neuropathy, major depression, or schizophrenia)
• Current use of prescribed or over the counter pain medications
• Previous adverse reaction to opiate medications or diphenhydramine
• Use of tobacco or caffeine on study days

Where it is running

• Behavioral Pharmacology Research Unit — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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