Atherosclerosis in Rheumatoid Arthritis

Completed

Conditions studied: Rheumatoid Arthritis, Endothelial Dysfunction

In brief

The purpose of this study is to investigate the link between rheumatoid arthritis and cardiovascular disease by studying inflammation, joint disease, cholesterol abnormalities, and endothelial function.

Key facts

Study ID

NCT00990730

Run by

University of California, San Francisco

People needed

80

Starts

2009-09-01

Expected to finish

2011-06-01

Last updated by the study team

2012-01-25

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Diagnosis of RA by ACR criteria
• Age 18-80
• Enrolled in UCSF RA cohort already

You may not qualify if…

• Diabetes (on meds or in medical history)
• Pregnant or Lactating
• Renal failure (Creatinine > 2mg/dL or on dialysis)
• History of MI or CAD
• History of ischemic CVA
• Symptomatic PVD
• Current uncontrolled hypertension (blood pressure > 160/100mmHg)
• Daily prednisone > 10mg daily
• Current smoker
• New BP med within 3 months
• New statin within 3 months
• Change in RA meds: new or increase in prednisone within 1 month, new TNF inhibitor within 2 months, titration of methotrexate, leflunomide or sulfasalazine within 3 months.

Where it is running

• UCSF San Francisco General Hospital Vascular Research Center — San Francisco, California, United States

Full record on ClinicalTrials.gov

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