A Study In Healthy Volunteers To Estimate The Pharmacokinetics Of Four Modified-Release Formulations Of Dimebon (Latrepirdine)

Completed · Phase 1

Conditions studied: Alzheimer's Disease, Huntington Disease

In brief

This study will evaluate four different modified release formulation to estimate the amount of dimebon available to the body relative to the current dimebon formulation that is given three times a day. The results of this study will help inform and guide further formulation development efforts with the ultimate goal of reducing dose frequency to once-a-day or twice-a-day.

Key facts

Study ID

NCT00988624

Run by

Pfizer

People needed

20

Starts

2009-10-01

Expected to finish

2009-12-01

Last updated by the study team

2010-01-12

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy male and/or female subjects between the ages of 18 and 55 years, inclusive.
• Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight >50 kg (110 lbs).

You may not qualify if…

• Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at time of dosing).
• Subjects with any history of a previous seizure (including childhood febrile seizures) or convulsion or significant head trauma.
• Subjects with hypersensitivity reactions to dimebon or other antihistamines.
• Any condition possibly affecting drug absorption (eg, gastrectomy).
• Smokers who use greater than 5 cigarettes per day.
• Use of proton pump inhibitors, antacids, and H2-blockers are prohibited for the duration of the study.
• Pregnant or nursing females; females of childbearing potential who are unwilling or unable to use an acceptable method of non-hormonal contraception.

Where it is running

• Pfizer Investigational Site — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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