Effect of Succinylcholine on Patients Using Statins
Completed · Not applicable
Conditions studied: Pain
In brief
Based on available mechanistic and clinical information, the investigators propose a nonrandomized study to evaluate the effect of succinylcholine in patients taking statins. The investigators' purpose is to evaluate the effect of succinylcholine on patients taking statins. Patients scheduled to undergo elective surgery (other then orthopedic, spinal, vascular or muscle) with planned endotracheal intubation will be approached regarding participation in the trial. Design of the study is complex because there is no way to randomize patients to statins or no statins and also no way to take them off the statins prior surgery. So statin use will not be randomized; confounding factors will be accounted for by stratification (every 10 years of age from 40-80 and gender) and statistical adjustment. The investigators propose to test the hypothesis that succinylcholine administration increases plasma myoglobin concentration more in patients who are on statins compared to patients who do not.
Key facts
- Study ID
- NCT00986583
- Run by
- The Cleveland Clinic
- People needed
- 70
- Starts
- 2009-09-01
- Expected to finish
- 2010-07-01
- Last updated by the study team
- 2016-10-03
Who can join
Age: 40 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Scheduled for elective surgery not involving orthopedic procedure, muscle and spinal surgery
- ASA Physical Status 1-3
You may not qualify if…
- History of liver failure
- History of renal failure
- History of neuromuscular disease
- Increased intraocular pressure
- Recent major burn
- Multiple trauma
- Susceptibility to or family history of malignant hyperthermia
Where it is running
- Cleveland Clinic Foundation — Cleveland, Ohio, United States
Full record on ClinicalTrials.gov
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