Clinical Trial of Intravitreal Microplasmin in Infants and Children Scheduled for Vitrectomy

Completed · Phase 2 · Has a placebo group

Conditions studied: Vitrectomy

In brief

To evaluate the safety and preliminary efficacy of intravitreal microplasmin as an adjunct to conventional vitrectomy for the treatment of pediatric patients.

Key facts

Study ID

NCT00986362

Run by

ThromboGenics

People needed

24

Starts

2010-02-01

Expected to finish

2012-04-01

Last updated by the study team

2014-12-17

Who can join

Age: any, up to 16. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female infants or children 16 years of age or younger
• Patient must be a suitable candidate for conventional 2-port or 3-port pars plana vitrectomy
• Patient with attached vitreous somewhere in posterior pole
• Patient's parent or guardian must be willing and able to comply with follow-up requirements
• Patient's parent(s) must sign informed parental permission form and in the case of school-age children the patient must sign assent form

You may not qualify if…

• Patient diagnosed with Stage 1, 2, 3 or 5 retinopathy of prematurity (ROP) at the time of surgery
• Unclear media, which precludes assessment of the posterior pole such as a cataract or vitreal opacity
• Active parental/guardian drug or alcohol use or dependence that, in the opinion of the site Investigator, would interfere with parent's or guardian's adherence to study requirements
• Medical problems that make consistent follow-up over the treatment period uncertain.
• Patient must not have participated in an investigational drug or device study in the prior 30 days
• Female Patients of childbearing potential must not be pregnant or lactating.

Where it is running

• Associated Retina Consultants — Royal Oak, Michigan, United States

Full record on ClinicalTrials.gov

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