TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)

Recruiting now

Conditions studied: Cardiovascular Diseases

In brief

Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small pieces of heart tissue from patients undergoing heart surgery before and after this period of ischemia. This will be compared to blood gene expression in blood cells and analyzed with the patients' genetic profile. This might allow us to assess the amount of inflammation that occurs when patients are on the heart-lung machine as well as examine the effects genes have on this critical time period.

Key facts

Study ID

NCT00985049

Run by

Brigham and Women's Hospital

People needed

350

Starts

2009-03-01

Expected to finish

2025-12-01

Last updated by the study team

2024-08-22

Who can join

Age: 20 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged greater than 20 years
• Undergoing aortic valve surgery with or without CABG surgery
• Receive and apical vent as part of the surgery

You may not qualify if…

• Will not receive an apical left ventricular vent

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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