Intravascular Ultrasound Derived Virtual Histology and Intracoronary Serum Markers of Inflammation
Stopped early
Conditions studied: Coronary Artery Disease, Atherosclerosis, Myocardial Infarction, Heart Failure, Angina
In brief
Patients enrolled will need treated with an IVUS- VH (intravascular ultrasound-derived virtual histology) which is an arterial stent procedure, that involves threading a tiny wire into the artery, followed by a balloon, a stent, or other device to treat a blocked artery, and often (though not always), a special ultrasound catheter to take pictures of the inside of the artery. Participants in the study, will have an additional procedure performed: a tiny tube will be advanced into the heart artery to collect a blood sample for research purposes, and a blood sample will be collected from the femoral (thigh) artery through the tube that will be placed there as a standard part of having this procedure. The blood that is collected will be analyzed for markers of inflammation or irritation in the blood (c-reactive protein, myeloperoxidase, Monocyte chemotactic protein-1), as well and a gene called Matrix Metallopeptidase 3, which is believe to influence the progression of plaque on the walls of arteries and the progression of coronary artery disease. .
Key facts
- Study ID
- NCT00982852
- Run by
- Quinn Capers
- People needed
- 9
- Starts
- 2008-12-01
- Expected to finish
- 2010-12-01
- Last updated by the study team
- 2013-07-12
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- In- or out-patients admitted to IPR or hospital floor for left heart catheterization or scheduled angioplasty
- 18 years or older
- Able to provide informed consent
You may not qualify if…
- Patients who are pregnant or lactating
- Inability to provide informed consent
- Patients undergoing heart catheterization for who open heart surgery is planned
- Anticipate being unavailable for telephone follow-up
Where it is running
- The Ohio State University Medical Center — Columbus, Ohio, United States
Full record on ClinicalTrials.gov
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