A Trial Of CVX-060, An Anti-Angiogenic COVX-Body, In Combination With Sunitinib In Patients With Advanced Renal Cell Carcinoma

Stopped early · Phase 2

Conditions studied: Solid Tumor

In brief

The safety and tolerability of CVX-060 have been established in the first-in-human clinical trial, CVX-060-101. Thus, this phase Ib/II trial is to assess the safety and pharmacokinetics (PK) profiles of combining CVX-060 with sunitinib in patients with advanced solid tumors, and to subsequently assess the treatment efficacy of the combination treatment, as well as that of sunitinib alone in patients with advanced renal cell carcinoma (mRCC).

Key facts

Study ID

NCT00982657

Run by

Pfizer

People needed

34

Starts

2009-09-01

Expected to finish

2014-03-01

Last updated by the study team

2015-11-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically or cytologically confirmed advanced/metastatic solid tumor
• Having received at least 1 prior systemic therapy for the treatment of advanced/metastatic solid tumors
• Histologically or cytologically confirmed renal cell carcinoma with clear cell histology and evidence of metastasis (No previous systemic therapy for the treatment of metastatic renal cell carcinoma)
• Adequate laboratory tests
• Eastern Cooperative Oncology Group (ECOG) 0-1, Life expectancy > or = 12 weeks and age > or = 18 years

You may not qualify if…

• Patients intolerant of prior anti-angiogenic agents
• Recent history of bleeding or bleeding disorders
• History of tumors in the brain
• History of heart problems
• History of severe allergic reaction to antibody therapy

Where it is running

• Premiere Oncology of Arizona — Scottsdale, Arizona, United States
• Premiere Oncology, A Medical Corporation — Santa Monica, California, United States
• Boston Baskin Cancer Foundation — Southaven, Mississippi, United States
• Providence Portland Medical Center — Portland, Oregon, United States
• Boston Baskin Cancer Foundation — Bartlett, Tennessee, United States
• Boston Baskin Cancer Foundation — Germantown, Tennessee, United States
• Boston Baskin Cancer Foundation — Memphis, Tennessee, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.