First-line Treatment of Patients With Stage IV Nonsquamous Non-Small Cell Lung Cancer With Necitumumab (IMC-11F8) and Pemetrexed-Cisplatin

Completed · Phase 3

Conditions studied: Non Small Cell Lung Cancer

In brief

The research study is testing the investigational drug necitumumab in the treatment of advanced non-small cell lung cancer. The aim of this study is to determine if necitumumab, given together with a standard chemotherapy combination consisting of cisplatin and pemetrexed will be more effective in improving participant disease than the standard chemotherapy combination alone.

Key facts

Study ID: NCT00982111
Run by: Eli Lilly and Company
People needed: 633
Starts: 2009-11-02
Expected to finish: 2020-12-23
Last updated by the study team: 2022-01-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Has histologically or cytologically confirmed nonsquamous (adenocarcinoma/large cell or other) non small cell lung cancer
Has Stage IV disease at the time of study entry
Measurable or nonmeasurable disease (as defined by the Response Evaluation Criteria in Solid Tumors RECIST 1.0) at the time of study entry (participants with only truly nonmeasurable disease are not eligible)
Has resolution to Grade ≤ 1 of all clinically significant toxic effects of prior chemotherapy, surgery, radiotherapy, or hormonal therapy (with the exception of alopecia)
Has an Eastern Cooperative Oncology Group performance status score of 0-2
Has adequate hepatic function
Has adequate renal function
Has adequate hematologic function
If female, is surgically sterile, postmenopausal, or compliant with a highly effective contraceptive method during and for 6 months after the treatment period (oral hormonal contraception alone is not considered highly effective and must be used in combination with a barrier method). If male, the participants surgically sterile or compliant with a highly effective contraceptive regimen during and for 6 months after the treatment period
Female participants of childbearing potential must have a negative serum

You may not qualify if…

Has squamous non small cell lung cancer
Has received prior anticancer therapy with monoclonal antibodies, signal transduction inhibitors, or any therapies targeting the Epidermal Growth Factor Hormone (EGFR), vascular endothelial growth factor (VEGF), or VEGF receptor
Received previous chemotherapy for advanced NSCLC (participants who have received adjuvant chemotherapy are eligible if the last administration of the prior adjuvant regimen occurred at least 1 year prior to randomization)
Undergone major surgery or received any investigational therapy in the 4 weeks prior to randomization
Undergone chest irradiation within 12 weeks prior to randomization (except palliative irradiation of bone lesions, which is allowed)
Has brain metastases that are symptomatic or require ongoing treatment with steroids or anticonvulsants. Participants who have undergone previous radiotherapy for brain metastases, who are now nonsymptomatic and no longer require treatment with steroids or anticonvulsants, are eligible
Has superior vena cava syndrome contraindicating hydration
Has current clinically-relevant coronary artery disease or uncontrolled congestive heart failure
Has experienced myocardial infarction within 6 months prior to randomization
Has an ongoing or active infection (requiring antibiotics), including active tuberculosis or known infection with the human immunodeficiency virus
Has a history of significant neurological or psychiatric disorders, including dementia, seizures, or bipolar disorder, potentially precluding protocol compliance
Has Grade ≥ 2 peripheral neuropathy
Has significant third space fluid retention, requiring repeated drainage
Has any other serious uncontrolled medical disorders or psychological conditions that would, in the opinion of the investigator, limit the participant's ability to complete the study or sign an informed consent document The participant has a known allergy / history of hypersensitivity reaction to any of the treatment components, including any ingredient used in the formulation of IMC-11F8, or any other contraindication to one of the administered treatments
Is pregnant or breastfeeding
Has a known history of drug abuse
Has a concurrent active malignancy other than adequately-treated basal cell carcinoma of the skin or preinvasive carcinoma of the cervix. A participant with previous history of malignancy other than NSCLC is eligible, provided that he/she has been free of disease for ≥ 3 years

Where it is running

ImClone Investigational Site — Kogarah, New South Wales, Australia
ImClone Investigational Site — Hobart, Tasmania, Australia
ImClone Investigational Site — East Bentleigh, Victoria, Australia
ImClone Investigational Site — Rankweil, Austria
ImClone Investigational Site — Vienna, Austria
ImClone Investigational Site — Vienna, Austria
ImClone Investigational Site — Duffel, Belgium
ImClone Investigational Site — Liège, Belgium
ImClone Investigational Site — Namur, Belgium
ImClone Investigational Site — Barretos - SP, Brazil
ImClone Investigational Site — Brasilia, Distrito Federal, Brazil
ImClone Investigational Site — Goiania - GO, Brazil
ImClone Investigational Site — Ijuí, Brazil
ImClone Investigational Site — Itajaí, Brazil
ImClone Investigational Site — Lajeado, Brazil
ImClone Investigational Site — Porto Alegre/RS, Brazil
ImClone Investigational Site — Ribeirão Preto - SP, Brazil
ImClone Investigational Site — Salvador, Brazil
ImClone Investigational Site — Santo Andre - SP, Brazil
ImClone Investigational Site — São Paulo - SP, Brazil
ImClone Investigational Site — Montreal, Quebec, Canada
ImClone Investigational Site — Pula, Croatia
ImClone Investigational Site — Caen, France
ImClone Investigational Site — Paris, France
ImClone Investigational Site — Nyack, New York, United States

Full record on ClinicalTrials.gov

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