Nutrigenomics of Zinc Supplementation in Insulin Secretion and Diabetes

Completed · Not applicable

Conditions studied: Diabetes

In brief

The purpose of this study is to evaluate the effect of zinc supplementation on insulin secretion by genotype of SLC30A8.

Key facts

Study ID

NCT00981448

Run by

University of Maryland, Baltimore

People needed

57

Starts

2009-09-01

Expected to finish

2012-04-01

Last updated by the study team

2022-01-20

Who can join

Age: 21 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• aged 21-70 years
• Amish decent
• genotyping of rs13266634 of SLC30A8 gene
• previously consented to contact for future studies and future use of DNA

You may not qualify if…

• Subject is a first-degree relative of another subject with the same SLC30A8 genotype
• diabetes mellitus (by history, treatment or random BG>200 mg;dl)
• gastrointestinal disease causing nausea, vomiting, or diarrhea including inflammatory bowel disease by history.
• rheumatoid arthritis by history
• albumin < 3.5 g/dL
• hemochromatosis by history
• hematocrit <34%
• liver disease by history
• alanine aminotransferase or aspartate aminotransferase greater than 2.5 times normal
• renal failure by history
• estimated glomerular filtration rate < 60 mL/min by MDRD equation
• use of thiazide diuretic and unwilling to discontinue if deemed safe in the opinion of the treating physician and study physician for 1 week prior to protocol initiation
• use of systemic corticosteroid and unwilling to discontinue if deemed safe in the opinion of the treating physician and study physician for 1 week prior to protocol initiation
• use of highly-active antiretroviral medications
• use of antipsychotic medications
• use of quinolone antibiotics
• use of tetracycline antibiotic and unwilling to discontinue if deemed safe in the opinion of the treating physician and study physician for 1 week prior to protocol initiation
• use of chelation therapy in the past month
• unwilling to withdraw from supplements for 1 week prior to the study and throughout study
• abnormal thyroid stimulating hormone (TSH) level
• serious disease precluding participation
• reported pregnancy or positive urine hCG test
• cancer diagnosis in past 2 years
• breastfeeding
• use of denture adhesive

Where it is running

• Amish Research Clinic — Lancaster, Pennsylvania, United States

Full record on ClinicalTrials.gov

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