A Study To Investigate Whether PF-04457845 Is Effective In Treating Pain, Is Safe And Tolerable In Patients With Osteoarthritis Of The Knee
Completed · Phase 2 · Has a placebo group
Conditions studied: Osteoarthritis, Knee
In brief
Inactivation of the FAAH (Fatty Acid Amide Hydrolase) enzyme has been shown to relieve pain and inflammation in animal studies. PF-04457845 has been shown to inactivate the FAAH enzyme in animals and healthy human volunteers. The purpose of this study is to evaluate whether PF-04457845 can inactivate the FAAH enzyme in patients experiencing pain due to OA and whether this results in these patients experiencing less pain.
Key facts
- Study ID
- NCT00981357
- Run by
- Pfizer
- People needed
- 76
- Starts
- 2009-11-01
- Expected to finish
- 2010-05-01
- Last updated by the study team
- 2017-09-19
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects must have a diagnosis of Osteoarthritis (OA) of the knee confirmed by X-ray
- Subjects must be willing and able to stop all current pain therapy for the duration of study. (Limited and specific pain therapy will be available throughout the study)
- Subjects can be male or female between the ages of 18 and 75 years inclusive, but female subjects must not be able become pregnant
You may not qualify if…
- Subjects must not have any condition or medical history that might interfere with their ability to complete the study assessments
Where it is running
- Arthritis & Rheumatic Care Center — Miami, Florida, United States
- Miami Research Associates — Miami, Florida, United States
- Vince and Associates Clinical Research — Overland Park, Kansas, United States
- Vince and Associates Clinical Research — Overland Park, Kansas, United States
- CEDRA Clinical Research, LLC — San Antonio, Texas, United States
- Diex Research Inc. — Sherbrooke, Quebec, Canada
- Centrum for klinisk provning — Gothenburg, Sweden
Full record on ClinicalTrials.gov
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