Cluster Randomized Trial of Hospitals to Assess Impact of Targeted Versus Universal Strategies to Reduce Methicillin-resistant Staphylococcus Aureus (MRSA) in Intensive Care Units (ICUs)

Completed · Not applicable

Conditions studied: Methicillin-resistant Staphylococcus Aureus

In brief

The Randomized Evaluation of Decolonization versus Universal Clearance to Eliminate MRSA (REDUCE MRSA) Trial is a cluster randomized trial of the comparative effectiveness of three strategies to prevent methicillin-resistant Staphylococcus aureus (MRSA) in intensive care units. The three strategies to be evaluated are: * screening on admission followed by isolation of MRSA+ patients * screening on admission followed by isolation and decolonization of MRSA+ patients * universal decolonization on admission with no screening. The decolonization regimen involves bathing with chlorhexidine plus intra-nasal application of mupirocin. The main outcome will be MRSA+ clinical cultures. The study is a partnership between the CDC, the CDC Prevention Epicenters, and the Hospital Corporation of America.

Key facts

Study ID

NCT00980980

Run by

Harvard Pilgrim Health Care

People needed

74256

Starts

2009-09-01

Expected to finish

2011-09-01

Last updated by the study team

2017-05-02

Who can join

Age: 13 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Inclusion criteria will include all HCA hospitals that reside in US states where physicians do NOT routinely prescribe decolonization for MRSA + ICU patients.

You may not qualify if…

• Exclusion criteria will include hospitals where ICU physicians often prescribe decolonization for MRSA+ ICU patients.
• Dedicated burn ICUs will also be excluded due to the inability to perform routine bathing.
• Finally, since the intent is to assess the intervention in adult ICUs, pediatric hospitals will be excluded although patients <13 years old that are admitted to participating adult ICUs will be included in the unit-based intervention.

Where it is running

• Alaska Regional — Anchorage, Alaska, United States
• Los Robles Hosp & Med Ctr — Thousand Oaks, California, United States
• The Medical Center of Aurora — Aurora, Colorado, United States
• Blake Medical Center — Brandenton, Florida, United States
• Brandon Hospital — Brandon, Florida, United States
• Columbia Hosp Corp S Broward (Westside) — Fort Lauderdale, Florida, United States
• Palms West Hospital — Fort Lauderdale, Florida, United States
• Plantation General — Fort Lauderdale, Florida, United States
• Regional Med Cr Bayonet Point — Hudson, Florida, United States
• Largo Medical Center — Largo, Florida, United States
• Community Hospital — New Port Richey, Florida, United States
• Orange Park Med Ctr — Orange Park, Florida, United States
• Fawcett Memorial Hospital — Port Charlotte, Florida, United States
• Doctors Hospital of Sarasota — Sarasota, Florida, United States
• South Bay Hospital — Sun City Center, Florida, United States
• Capital Regional Med Ctr — Tallahassee, Florida, United States
• Coliseum (Macon) Northside — Macon, Georgia, United States
• Coliseum Medical Center — Macon, Georgia, United States
• Cartersville Medical Center — Tucker, Georgia, United States
• Eastern Idaho Reg Med Ctr — Idaho Falls, Idaho, United States
• Garden Park Medical Center — Gulfport, Mississippi, United States
• Lee's Summit Medical Center — Kansas City, Missouri, United States
• Menorah Medical Center — Kansas City, Missouri, United States
• Overland Park Regional Hospital — Kansas City, Missouri, United States
• Research Belton Hospital — Kansas City, Missouri, United States

Full record on ClinicalTrials.gov

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