Chemotherapy and Pelvic Radiation Therapy With or Without Additional Chemotherapy in Treating Patients With High-Risk Early-Stage Cervical Cancer After Radical Hysterectomy
Completed · Phase 3
Conditions studied: Cervical Cancer
In brief
RATIONALE: Drugs used in chemotherapy, such as cisplatin, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known whether chemotherapy and radiation therapy are more effective when given with or without additional chemotherapy in treating cervical cancer. PURPOSE: This randomized phase III trial is studying chemotherapy and pelvic radiation therapy to see how well they work when given with or without additional chemotherapy in treating patients with high-risk early-stage cervical cancer after radical hysterectomy.
Key facts
- Study ID
- NCT00980954
- Run by
- Radiation Therapy Oncology Group
- People needed
- 236
- Starts
- 2009-09-01
- Expected to finish
- 2025-09-04
- Last updated by the study team
- 2025-12-31
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
Where it is running
- Providence Hospital — Mobile, Alabama, United States
- Providence Alaska Medical Center — Anchorage, Alaska, United States
- Arizona Center for Cancer Care-Peoria — Peoria, Arizona, United States
- Saint Joseph's Hospital and Medical Center — Phoenix, Arizona, United States
- Providence Saint Joseph Medical Center/Disney Family Cancer Center — Burbank, California, United States
- Mercy San Juan Medical Center — Carmichael, California, United States
- City of Hope Medical Center — Duarte, California, United States
- Saint Joseph Hospital - Orange — Orange, California, United States
- Pomona Valley Hospital Medical Center — Pomona, California, United States
- Mercy Cancer Center — Sacramento, California, United States
- Mercy General Hospital Radiation Oncology Center — Sacramento, California, United States
- University of California At San Diego — San Diego, California, United States
- Saint Helena Hospital — St. Helena, California, United States
- Penrose-Saint Francis Healthcare — Colorado Springs, Colorado, United States
- Hartford Hospital — Hartford, Connecticut, United States
- The Hospital of Central Connecticut — New Britain, Connecticut, United States
- University of Miami Sylvester Comprehensive Cancer Center at Deerfield Beach — Deerfield Beach, Florida, United States
- Memorial Healthcare System - Joe DiMaggio Children's Hospital — Hollywood, Florida, United States
- Jackson Memorial Hospital-Holtz Children's Hospital — Miami, Florida, United States
- University of Miami Miller School of Medicine-Sylvester Cancer Center — Miami, Florida, United States
- Baptist Hospital of Miami — Miami, Florida, United States
- Florida Hospital — Orlando, Florida, United States
- Grady Health System — Atlanta, Georgia, United States
- Northside Hospital — Atlanta, Georgia, United States
- University of Alabama at Birmingham — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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