Studying the Effects of Antihypertensives on Individuals at Risk for Alzheimer's

Completed · Phase 4 · Has a placebo group

Conditions studied: Alzheimer's Disease, Hypertension

In brief

Angiotensin converting enzyme inhibitors (ACE-I) are a group of blood pressure-lowering medicines. Some studies suggest that ACE-I, such as ramipril, may help prevent Alzheimer's disease (AD). The purpose of the research is to see how ramipril affects a substance in the body called beta-amyloid. Beta-amyloid is found in the brain and in the liquid around the brain and spinal cord. High amounts of beta-amyloid may be associated with a greater risk of getting Alzheimer's disease. This study will see if ramipril can lower the amount of beta-amyloid in the spinal fluid. This study will also see if ramipril affects blood vessel function and memory and thinking. The investigators hope that future studies will show whether ramipril might prevent memory loss and decrease the chance of developing Alzheimer's disease.

Key facts

Study ID

NCT00980785

Run by

University of Wisconsin, Madison

People needed

14

Starts

2009-04-09

Expected to finish

2011-07-26

Last updated by the study team

2020-08-25

Who can join

Age: 40 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Between the ages of 40 and 65
• Mean resting blood pressure between 130-160 systolic and 85-100 diastolic
• Parent with Alzheimer's Disease

You may not qualify if…

• Current involvement in another investigational drug trial.
• Potassium > 5.0
• Dementia based on DSMIV criteria
• Mini-Mental State Exam (MMSE) score < 27
• Current blood pressure medication (< 4 months from screening)
• Weight loss medication
• Contraindications for LP
• Know diagnosis or history of hospitalization due to congestive heart failure
• Elevated creatinine (females > 1.3 mg/dL or males > 1.4 mg/dL at baseline)
• Diabetes Type I and II
• Know adverse reaction to an ACE-I or an angiotensin receptor blocker
• Pregnant of nursing women

Where it is running

• Wisconisn Alzheimer's Disease Research Center — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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