Chemotherapy and Radiation Therapy With or Without Panitumumab in Treating Patients With Stage IIIA Non-Small Cell Lung Cancer
Completed · Phase 2
Conditions studied: Lung Cancer
In brief
RATIONALE: Drugs used in chemotherapy (CT), such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy (RT) uses high-energy x-rays to kill tumor cells. Monoclonal antibodies, such as panitumumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Giving these treatments before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. It is not yet known whether chemotherapy and radiation therapy are more effective when given with or without panitumumab in treating patients with non-small cell lung cancer. PURPOSE: This randomized phase II trial is studying chemotherapy and radiation therapy to see how well they work when given with or without panitumumab in treating patients with stage IIIA non-small cell lung cancer.
Key facts
- Study ID
- NCT00979212
- Run by
- Radiation Therapy Oncology Group
- People needed
- 71
- Starts
- 2011-02-01
- Expected to finish
- 2022-05-20
- Last updated by the study team
- 2022-06-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Mercy Cancer Center at Mercy San Juan Medical Center — Carmichael, California, United States
- Radiological Associates of Sacramento Medical Group, Incorporated — Sacramento, California, United States
- Penrose Cancer Center at Penrose Hospital — Colorado Springs, Colorado, United States
- Lucille P. Markey Cancer Center at University of Kentucky — Lexington, Kentucky, United States
- CCOP - Ochsner — New Orleans, Louisiana, United States
- Greenebaum Cancer Center at University of Maryland Medical Center — Baltimore, Maryland, United States
- St. Agnes Hospital Cancer Center — Baltimore, Maryland, United States
- Cancer Institute at St. Joseph Medical Center — Towson, Maryland, United States
- Boston University Cancer Research Center — Boston, Massachusetts, United States
- Fairview Southdale Hospital — Edina, Minnesota, United States
- Virginia Piper Cancer Institute at Abbott - Northwestern Hospital — Minneapolis, Minnesota, United States
- Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis — St Louis, Missouri, United States
- Methodist Estabrook Cancer Center — Omaha, Nebraska, United States
- NYU Cancer Institute at New York University Medical Center — New York, New York, United States
- James P. Wilmot Cancer Center at University of Rochester Medical Center — Rochester, New York, United States
- Summa Center for Cancer Care at Akron City Hospital — Akron, Ohio, United States
- Charles M. Barrett Cancer Center at University Hospital — Cincinnati, Ohio, United States
- Cleveland Clinic Taussig Cancer Center — Cleveland, Ohio, United States
- Natalie Warren Bryant Cancer Center at St. Francis Hospital — Tulsa, Oklahoma, United States
- Bryn Mawr Hospital — Bryn Mawr, Pennsylvania, United States
- Adams Cancer Center — Gettysburg, Pennsylvania, United States
- Cherry Tree Cancer Center — Hanover, Pennsylvania, United States
- Cancer Center of Paoli Memorial Hospital — Paoli, Pennsylvania, United States
- Kimmel Cancer Center at Thomas Jefferson University - Philadelphia — Philadelphia, Pennsylvania, United States
- Fox Chase Cancer Center - Philadelphia — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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