Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma
Running, not enrolling · Phase 3
Conditions studied: Brain and Central Nervous System Tumors, Neurotoxicity
In brief
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether radiation therapy is more effective when given together with or without temozolomide in treating patients with low-grade glioma. PURPOSE: This randomized phase III trial is studying radiation therapy so see how well it works when given together with or without temozolomide in treating patients with low-grade glioma.
Key facts
- Study ID
- NCT00978458
- Run by
- Eastern Cooperative Oncology Group
- People needed
- 540
- Starts
- 2009-11-17
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2025-09-08
Who can join
Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Arizona Oncology Services Foundation — Phoenix, Arizona, United States
- Rebecca and John Moores UCSD Cancer Center — La Jolla, California, United States
- Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center — Orange, California, United States
- Aurora Presbyterian Hospital — Aurora, Colorado, United States
- St. Anthony Central Hospital — Denver, Colorado, United States
- Porter Adventist Hospital — Denver, Colorado, United States
- Presbyterian - St. Luke's Medical Center — Denver, Colorado, United States
- St. Joseph Hospital — Denver, Colorado, United States
- CCOP - Colorado Cancer Research Program — Denver, Colorado, United States
- Swedish Medical Center — Englewood, Colorado, United States
- Sky Ridge Medical Center — Lone Tree, Colorado, United States
- Eastern Connecticut Hematology and Oncology Associates — Norwich, Connecticut, United States
- CCOP - Christiana Care Health Services — Newark, Delaware, United States
- Mayo Clinic - Jacksonville — Jacksonville, Florida, United States
- Florida Hospital Cancer Institute at Florida Hospital Orlando — Orlando, Florida, United States
- Winship Cancer Institute of Emory University — Atlanta, Georgia, United States
- Illinois CancerCare - Bloomington — Bloomington, Illinois, United States
- St. Joseph Medical Center — Bloomington, Illinois, United States
- Graham Hospital — Canton, Illinois, United States
- Illinois CancerCare - Canton — Canton, Illinois, United States
- Illinois CancerCare - Carthage — Carthage, Illinois, United States
- Memorial Hospital — Carthage, Illinois, United States
- Robert H. Lurie Comprehensive Cancer Center at Northwestern University — Chicago, Illinois, United States
- John H. Stroger, Jr. Hospital of Cook County — Chicago, Illinois, United States
- UAB Comprehensive Cancer Center — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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