Microenvironment of Adipose Tissue in Endocannabinoid System

Completed

Conditions studied: Obesity

In brief

The purpose of this study is examine the relationship between adipose tissue inflammation and activation of the endocannabinoid system before and after Roux-en-Y gastric bypass surgery. The investigators hypothesize that the metabolic improvements and weight loss are due to mechanisms that antagonize the endocannabinoid system.

Key facts

Study ID

NCT00978289

Run by

Vanderbilt University

People needed

20

Starts

2008-07-01

Expected to finish

2012-12-01

Last updated by the study team

2013-06-19

Who can join

Age: 20 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• BMI>35 kg/m2
• Age 20-60 yrs
• Approved and scheduled for gastric bypass surgery
• Stable body weight for past 3 months

You may not qualify if…

• Positive pregnancy test
• Previous gastric surgeries
• Intercurrent infections
• History of ketoacidosis or current metabolic acidosis
• Serum creatinine or liver function tests > 2 times upper limits of normal
• Taking drugs that are known to affect carbohydrate or lipid metabolism other than anti-diabetes mediations.

Where it is running

• Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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