Microbiota of the Respiratory Flora in Children With Cystic Fibrosis During the First Year of Life
Withdrawn before enrolling
Conditions studied: Cystic Fibrosis
In brief
The goal of this study is characterize the changes in bacterial diversity of the upper respiratory tracts of infants with cystic fibrosis (CF). Another goal is to determine when CF patients become colonized with pathogenic bacteria that are responsible for the lethal lung damage in children with CF. Ten subjects will be recruited into the study. Throat swabs will be collected at 6-8 weeks of age, 3 months, 6 months, 9 months, and 12 months of age in order to chart any changes in the bacterial populations of the respiratory tract. Clinical data will also be collected to evaluate the possible influence of external factors on changes in the microbial communities. This study will provide preliminary data on whether probiotics can eradicate the colonization of the respiratory tract by pathogenic bacteria.
Key facts
- Study ID
- NCT00977158
- Run by
- Tufts Medical Center
- People needed
- 0
- Starts
- 2011-05-01
- Last updated by the study team
- 2015-03-18
Who can join
Age: 0 and older, up to 0. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male and female subjects, newborn to age 3 months
- Have a diagnosis of cystic fibrosis (Diagnosis of CF will be based on either a positive sweat chloride of >60 mEq/L or the identification of two detectable mutations associated with CF
- Parent/guardian plans to have follow-up care for approximately one year at designated CF clinic
- Parent/guardian provides informed consent to participate in the study
You may not qualify if…
- Contraindications for obtaining oropharyngeal swabs
Where it is running
- Floating Hospital for Children at Tufts Medical Center — Boston, Massachusetts, United States
- Children's Hospital Boston — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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