Basiliximab #2: In-Vivo Activated T-Cell Depletion to Prevent Graft-Versus_Host Disease (GVHD) After Nonmyeloablative Allotransplantation for the Treatment of Blood Cancer

Completed · Phase 2

Conditions studied: Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia, Chronic Myelogenous Leukemia, Chronic Lymphocytic Leukemia, Myelodysplasia, Non-Hodgkin's Lymphoma, Hodgkin's Disease, Multiple Myeloma, Myelofibrosis, Anemia, Aplastic, Hemoglobinuria, Paroxysmal

In brief

The purpose of this study is to compare the effects (good and bad) of the medication basiliximab in combination with cyclosporine (investigational therapy) for the prevention of a complication of bone marrow transplantation known as graft-versus-host disease (GVHD). GVHD is a complication in which the cells of the transplanted bone marrow react against organs and tissues.

Key facts

Study ID

NCT00975975

Run by

Indiana University

People needed

17

Starts

2009-09-01

Expected to finish

2013-11-01

Last updated by the study team

2016-02-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Acute myelogenous leukemia:
• Second or subsequent remission; patient over 18 yrs of age.
• Relapsed after autologous HC transplant, over 18 years of age.
• First remission, Philadelphia chromosome + over age 18.
• Secondary AML, in first or subsequent remissions.
• Acute lymphocytic leukemia:
• Philadelphia chromosome + over the age of 50, first or subsequent remission.
• Relapse following Autologous HC transplantation, ages over 50.
• Second or subsequent remission over the age of 50
• Chronic myelogenous leukemia:
• First or second chronic phase over the age of 18.
• Accelerated phase over the age of 18.
• Must have failed or been intolerant to a standard tyrosine kinase inhibitor.
• Chronic lymphocytic leukemia:
• Failed nucleoside-based therapy, ages >18.
• Myelodysplasia:
• All-risk categories, age greater than 18.
• Non-Hodgkin's Lymphoma, less than 76 years of age
• Relapsed diffuse aggressive NHL (intermediate and high grade) that fails to achieve CR or PR to conventional salvage chemotherapy.
• Aggressive NHL includes diffuse large B cell lymphoma, diffuse mixed small and large cell lymphoma, follicular lymphoma for grade 3 (follicular large cell lymphoma), T or B cell lymphoblastic lymphoma, diffuse small noncleaved (Burkett's or Burkett-like ) lymphoma, mantle cell lymphoma, peripheral T cell lymphoma, anaplastic large cell lymphoma, and other diffuse aggressive lymphomas that are not otherwise classifiable
• Aggressive NHL that has relapsed following autologous HCT. Patients that respond to additional treatment for post-transplant relapse are eligible.
• Aggressive NHL that does not achieve CR or PR with primary chemotherapy (i.e., primary induction failure).
• Low-grade lymphoma refractory to standard therapy, including the following:
• small cell lymphocytic lymphoma,
• follicular lymphoma of grades 1 and 2 (follicular small cleaved and follicular mixed small and large cell lymphoma)

You may not qualify if…

• Active CNS disease (the presence of leukemic blasts in the CSF)
• Pregnancy or breast-feeding.
• Inability to give informed consent.
• AST, ALT, total bilirubin >3x upper limit of normal.
• Creatinine > 2 or creatinine clearance < 50mL/hr. If patient has a creatinine of > 2 or creatinine clearance < 50mL/hr and it is due to the disease process then the patient will not be excluded based on this.
• Fractional shortening by echocardiogram not within normal limits per institution or LVEF of < 40 %.
• Pulmonary function: DLCO not within institutional normal limits or DLCO less than 45% of normal predicted, corrected for anemia
• Prior allogeneic transplant.

Where it is running

• Indiana University Cancer Center — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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