The Relationship Between the Response to Mental Stress and Vascular Endothelial Function

Completed

Conditions studied: Coronary Endothelial Dysfunction, Apical Ballooning Syndrome, Myocardial Infarction

In brief

The aim of this study is to measure how different people respond to mental stress. The investigators will measure if there are differences in cardiovascular responses to mental stress among different groups of subjects. In one part of the study the investigators will compare the cardiovascular responses to mental stress between healthy women and healthy men. In another part of the study, the investigators will compare the cardiovascular responses to mental stress between women with apical ballooning syndrome and healthy post-menopausal women. The investigators hypothesize that healthy men will have an increased vascular response to and decreased endothelial function in response to to mental stress, compared to health women. Furthermore, the investigators hypothesize that women with apical ballooning syndrome will have an increased vascular response to and decreased endothelial function in response to mental stress.

Key facts

Study ID

NCT00975559

Run by

Mayo Clinic

People needed

190

Starts

2003-09-01

Expected to finish

2011-04-01

Last updated by the study team

2012-04-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients must be identified in one of the four groups outlined in "study population description."

You may not qualify if…

• Other co-morbidities that would make the testing not possible.
• Women who have had a mastectomy and would not have an arm that could be occluded during the reactive hyperemia portion of the Peripheral arterial tonometry testing.

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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