Vitamin D Deficiency in Patients With Hypertension
Stopped early · Phase 4 · Has a placebo group
Conditions studied: Vitamin D Deficiency, Hypertension
In brief
This study will evaluate the effects of Vitamin D replacement and the effects of an approved medication for hypertension, aliskiren (Tekturna), in patients with high blood pressure who have low levels of vitamin D in their blood. The study will compare the effects of vitamin D or aliskiren alone and in combination on 24-hour blood pressure and biochemical parameters.
Key facts
- Study ID
- NCT00974922
- Run by
- UConn Health
- People needed
- 40
- Starts
- 2009-08-01
- Expected to finish
- 2011-12-01
- Last updated by the study team
- 2018-03-09
Who can join
Age: 21 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Men or women over 21 years of age with a history of Stage 1 or 2 hypertension (defined as a seated diastolic BP ≥ 90 mmHg and < 110 mmHg in the untreated state).
- Patients under treatment for hypertension must be willing and able to discontinue any previous antihypertensive medications for the duration of the study.
- 25-hydroxyvitamin D levels < 30 ng/ml and > 12 ng/ml.
- Women of childbearing potential must be using a medically acceptable form of birth control for the duration of the trial, must have a negative serum pregnancy test at screening, and must have a negative urine pregnancy test within 7 days before initiating aliskiren therapy.
You may not qualify if…
- Vitamin D levels < 12 ng/ml
- Known hypersensitivity or allergy to aliskiren
- Clinic blood pressure > 180/110 mmHg
- Known forms of secondary hypertension
- Chronic atrial fibrillation
- Uncontrolled or unstable cardiovascular diseases
- Shift or night workers
- Mid-arm circumference > 42 cm in diameter
- Current or recent (<1 year) alcohol or drug abuse
- Pregnant or lactating women
Where it is running
- University of Connecticut Health Center — Farmington, Connecticut, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.