Blood Flow Responses to an Oral Glucose Tolerance Test in Type 2 Diabetes
Completed · Not applicable
Conditions studied: Type 2 Diabetes, Insulin Resistance
In brief
The investigators wish to determine whether a short period of exercise training (5-10 days) improves the metabolic and cardiovascular response of people with or at risk of developing type 2 diabetes to eating a meal. In healthy people, blood flow to skeletal muscles increases after eating a meal, and this helps to regulate blood sugar levels by delivering blood sugar to muscles where it can be stored or metabolized. In people with or at risk of type 2 diabetes, blood flow does not increase as much after eating a meal, and this may contribute to elevated blood sugar concentrations observed in these individuals. The investigators wish to determine whether exercise can improve this response.
Key facts
- Study ID
- NCT00972452
- Run by
- University of Kansas Medical Center
- People needed
- 30
- Starts
- 2009-08-01
- Expected to finish
- 2010-09-01
- Last updated by the study team
- 2015-09-24
Who can join
Age: 30 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Insulin resistant: diagnosed with pre-diabetes or fasting blood glucose >/= 100 mg/dL
- T2D: diagnosed by primary care physician
- BMI: less than 43 kg/m2
- Age: 30-65
You may not qualify if…
- Smoking
- Insulin use (other than once daily)
- Underlying conditions that limit ability to exercise safely
- Recent weight gain or loss (> 5% of body weight in 3 months)
- Physically active (> 30 min aerobic exercise, 2 d/wk)
- Recent (< 3 mo) changes in medication use or dose
- Uncontrolled T2D (HbA1c > 10%)
- Advanced retinopathy or neuropathy
- Pregnancy
Where it is running
- University of Kansas Medical Center — Kansas City, Kansas, United States
Full record on ClinicalTrials.gov
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