Oral Contraceptive (OC) Progestin Dose and Breast Proliferation

Completed · Not applicable

Conditions studied: Oral Contraceptive

In brief

The purpose of this research study is to gain a better understanding of the changes that may occur in the breast when a woman uses an oral contraceptive (birth control pill). Some research indicates that women who use birth control pills with lower amounts of progestin (a hormone in the birth control pill) may have lower breast cell growth than women who use birth control pills with a higher amount of progestin; this research will examine that in detail.

Key facts

Study ID

NCT00972439

Run by

University of Southern California

People needed

33

Starts

2007-08-01

Expected to finish

2008-11-01

Last updated by the study team

2018-02-23

Who can join

Age: 18 and older, up to 34. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Age 18-34.
• Premenopausal.
• Currently taking or want to start oral contraceptives for contraception
• Non-smoker.
• Competent to give informed consent (as judged by the investigator).
• Provided written informed consent.
• Willingness to refrain from smoking and consumption of grapefruit or grapefruit juice during the study (grapefruit interferes with metabolism of exogenously administered OCs).
• Exclusion Criteria:1.
• Abnormal breast examination.
• History or current therapeutic or prophylactic use of anticoagulants.
• Known bleeding disorder or history of unexplained bleeding or bruising.
• History of breast cancer or previous diagnostic breast biopsy.
• Known allergy to local anesthetic.
• Currently pregnant or pregnant within the previous 6 months.
• Having any standard contra-indication to being prescribed OCs.

Where it is running

• Los Angeles County Hospital — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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