Age, Lifestyle, Muscle Mechanisms in Insulin Resistance

Completed · Not applicable

Conditions studied: Obesity, Glucose Intolerance, Exercise Capacity

In brief

The purpose of this study is to investigate the mechanisms by which physical inactivity and obesity alter skeletal muscle insulin signaling to cause insulin resistance and increase the development of impaired glucose tolerance (IGT).

Key facts

Study ID

NCT00971594

Run by

National Institute on Aging (NIA)

People needed

15

Starts

2004-06-01

Expected to finish

2008-05-01

Last updated by the study team

2009-09-03

Who can join

Age: 50 and older. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Men older than 50 yrs of age
• Non-smoking (more than 5 years)
• BMI greater than 25 kg/m2 and less than 50 kg/m2

You may not qualify if…

• CAD, CHF, Myocardial infarction within 6 months or other symptomatic heart disease
• History of stroke, peripheral arterial disease
• Currently being treated for active cancer
• On oral agents or insulin therapy for diabetes
• Poorly controlled Dyslipidemia (abnormal concentration of lipids or lipoproteins in the blood)
• Poorly controlled hypertension (BP > 180/95)
• Other systematic disorders that are not medically treated and stable
• Physical impairment limiting normal activity and other contraindications to exercise
• Aerobically conditioned
• Abnormal response to exercise (chest pain, significant arrhythmias, extreme shortness of breath, cyanosis, exercising BP > 240/120)
• Taking warfarin/coumadin
• Taking oral steroids
• Abnormal renal function or liver function
• Chronic pulmonary disease severe enough to require oxygen
• Anemia
• MMSE < 24, dementia

Where it is running

• Baltimore VA Medical Center — Baltimore, Maryland, United States
• University of Maryland — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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