Olfactory Dysfunction of Rhinosinusitis - Cyclic Adenosine Monophosphate (cAMP)/Calcium Signaling Study

Completed

Conditions studied: Sinusitis

In brief

The study examines the biochemistry underlying human olfaction in both normal and diseased states. The study aims are: 1. to determine the levels of cAMP in olfactory tissue from people with chronic rhinosinusitis and other nasal disorders. 2. to correlate preoperative olfactory function with cAMP levels from biopsied olfactory tissue. 3. to determine odorant and pheromone-mediated activation of cultured human olfactory sensory neurons using calcium imaging and 4. to determine odorant and pheromone-mediated activation of cultured human olfactory sensory neurons using "smell-chip" technology.

Key facts

Study ID

NCT00970190

Run by

Greg Davis

People needed

99

Starts

2009-08-01

Expected to finish

2014-04-01

Last updated by the study team

2014-12-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects will be 18 years old and over and scheduled for one of the following:
• endoscopic sinus surgery for chronic sinusitis
• endoscopic transnasal approach to the pituitary for pituitary tumor removal
• endoscopic inferior turbinectomy or septoplasty for nasal congestion
• endoscopic repair of cerebrospinal fluid (CSF) leaks

You may not qualify if…

• Subjects are excluded if they are unable to give informed consent or unable to complete self-administered questionnaires due to English language barrier, cognitive impairment, or severe medical conditions

Where it is running

• University of Washington Medical Center — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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