Determinants of Fetal Inflammatory Exposure at Term

Completed

Conditions studied: Maternal-Fetal Relations

In brief

The hypothesis of this study is that maternal and fetal biologic variation in the balance between pro-inflammatory and anti-inflammatory mediators can be measured by currently available techniques. In addition, the investigators hypothesize that a pro-inflammatory maternal phenotype increases the risk of fetal exposure to intrauterine hyperthemia and inflammatory cytokines; and that intrapartum events, especially known risk factors for fever at term such as epidural analgesia and prolonged rupture of membranes, may interact with underlying maternal factors to increase fetal exposure to inflammatory cytokines. This experiment aims to establish the first large-scale cohort to evaluate biomarkers for maternal and fetal inflammation in term pregnancy and to elucidate the relative antepartum and intrapartum contributions to fetal inflammation.

Key facts

Study ID

NCT00970151

Run by

Medical University of South Carolina

People needed

618

Starts

2005-06-01

Expected to finish

2009-08-01

Last updated by the study team

2009-10-12

Who can join

Age: 14 and older, up to 48. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Nulliparity
• Singleton gestation
• Full term (>37 weeks) pregnancy
• Vertex presentation
• Candidate for trial of labor
• Ability to provide informed consent

You may not qualify if…

• Multiple gestation
• Autoimmune Disease
• Treatment with anti-inflammatory agents during pregnancy

Where it is running

• Medical Univeristy of South Carolina — Charleston, South Carolina, United States

Full record on ClinicalTrials.gov

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