Erlotinib Is Being Studied With Or Without An Investigational Drug, PF-02341066, In Patients With Lung Cancer

Completed · Phase 1

Conditions studied: Non-Small Cell Lung Cancer

In brief

This is a Phase 1/2 study comparing the safety and anti-tumor activity of erlotinib alone versus erlotinib in combination with PF-02341066 in patients with advanced non-small cell lung cancer.

Key facts

Study ID

NCT00965731

Run by

Pfizer

People needed

27

Starts

2010-01-01

Expected to finish

2014-01-01

Last updated by the study team

2015-10-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• histologically proven diagnosis of Non-Small Cell Lung Cancer (NSCLC) that is locally advanced or metastatic and of the adenocarcinoma subtype (including mixed adenosquamous histology)
• evident disease progression by Response Evaluation Criterion in Solid Tumors (RECIST) after at least one but no more than 2 chemotherapy regimens for advanced disease
• tumors must have measurable disease as per RECIST

You may not qualify if…

• known interstitial lung disease
• prior treatment with an agent that is known or proposed to be active by action on EGFR tyrosine kinase or c-Met/HGF (Phase 2 Portion)

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• University of Alabama at Birmingham — Birmingham, Alabama, United States
• University of California, Irvine Medical Center Pharmacy — Orange, California, United States
• University of California, Irving - Medical Center — Orange, California, United States
• University of California Irvin — Orange, California, United States
• Holy Cross Hospital — Fort Lauderdale, Florida, United States
• Siteman Cancer Center — City of Saint Peters, Missouri, United States
• Siteman Cancer Center -West County — Creve Coeur, Missouri, United States
• Barnes-Jewish Hospital — St Louis, Missouri, United States
• Washington University, School of Medicine — St Louis, Missouri, United States
• OSU East — Columbus, Ohio, United States
• The Ohio State University James Cancer Hospital — Columbus, Ohio, United States
• James Care in Kenny — Columbus, Ohio, United States
• Cancer Therapy & Research Center @ UTHSCSA — San Antonio, Texas, United States
• Seattle Cancer Care Alliance — Seattle, Washington, United States
• University of Washington Medical Center — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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