Once Weekly D-cycloserine for Schizophrenia

Withdrawn before enrolling · Phase 4 · Has a placebo group

Conditions studied: Schizophrenia

In brief

This is a parallel-group, placebo-controlled trial examining the cognitive effects at weeks 1, 4, \& 8 of once-weekly oral D-cycloserine 50 mg added to a stable dose of antipsychotic for 8 weeks in adult outpatients with schizophrenia.

Key facts

Study ID

NCT00964041

Run by

Massachusetts General Hospital

People needed

0

Starts

2009-07-01

Expected to finish

2011-06-01

Last updated by the study team

2013-11-20

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female
• Age 18-65 years
• Diagnosis of schizophrenia or schizoaffective disorder, depressed type
• Stable dose of antipsychotic for at least 4 weeks.
• Able to provide informed consent
• Able to complete a cognitive battery

You may not qualify if…

• Current treatment with clozapine
• Dementia
• Seizure disorder
• Unstable medical illness
• Active substance abuse
• Pregnancy, nursing, or unwilling to use appropriate birth control measures during participation if female and fertile.
• Severe renal insufficiency (Serum creatinine > 1.5 mg/dL)

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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