An 18 Week Efficacy and Safety Study of Saxagliptin and Metformin XR Combination in Subjects With Type 2 Diabetes

Completed · Phase 3

Conditions studied: Type 2 Diabetes

In brief

The purpose of this study is to compare reduction in A1C for subjects taking Saxagliptin and Metformin XR vs. uptitrated Metformin XR.

Key facts

Study ID

NCT00960076

Run by

AstraZeneca

People needed

282

Starts

2009-08-01

Expected to finish

2010-10-01

Last updated by the study team

2011-09-27

Who can join

Age: 18 and older, up to 78. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Type 2 diabetics taking metformin IR or XR greater than or equal to 850mg and less than or equal to 1500mg only for at least 8 weeks prior to screening
• A1c: 7.5-11% (at screening)
• BMI less than or equal to 45 kg/m2

You may not qualify if…

• Significant cardiovascular history
• Active liver disease, renal impairment

Where it is running

• Research Site — Jonesboro, Arkansas, United States
• Research Site — Anaheim, California, United States
• Research Site — Fountain Valley, California, United States
• Research Site — Los Angeles, California, United States
• Research Site — Pasadena, California, United States
• Research Site — Sacramento, California, United States
• Research Site — Gainesville, Florida, United States
• Research Site — Wellington, Florida, United States
• Research Site — Chicago, Illinois, United States
• Research Site — Springfield, Illinois, United States
• Research Site — Indianapolis, Indiana, United States
• Research Site — St Louis, Missouri, United States
• Research Site — Salisbury, North Carolina, United States
• Research Site — Wilmington, North Carolina, United States
• Research Site — Winston-Salem, North Carolina, United States
• Research Site — Columbus, Ohio, United States
• Research Site — Marion, Ohio, United States
• Research Site — Simpsonville, South Carolina, United States
• Research Site — Bristol, Tennessee, United States
• Research Site — Alexandria, Virginia, United States
• Research Site — Burke, Virginia, United States
• Research Site — Manassas, Virginia, United States
• Research Site — Barranquilla, Atlántico, Colombia
• Research Site — Barranquilla, Colombia
• Research Site — Bogotá, Colombia

Full record on ClinicalTrials.gov

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