Exercise Intolerance in Elderly Patients With Diastolic Heart Failure

Completed · Not applicable

Conditions studied: Heart Failure, Diastolic, Obesity

In brief

The purpose of this study is to examine the effects of weight loss via hypocaloric diet, aerobic exercise training, combined hypocaloric diet and exercise training, and attention control in patients with heart failure and a normal ejection fraction (HFNEF) and body mass index greater than or equal to 30.

Key facts

Study ID

NCT00959660

Run by

Wake Forest University

People needed

100

Starts

2009-02-01

Expected to finish

2013-08-01

Last updated by the study team

2019-02-15

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Heart failure clinical score greater than or equal to 3
• Age 60 and over
• Normal ejection fraction greater than or equal to 50%
• BMI greater than or equal to 30

You may not qualify if…

• Valvular heart disease
• Significant change in cardiac medication <4 weeks
• Uncontrolled hypertension
• Recent or debilitating stroke
• Cancer or other noncardiovascular conditions with life expectancy less than 2 years
• Significant Anemia
• Renal insufficiency (creatinine >2.5mg/dl)
• Psychiatric disease- uncontrolled major psychoses, depressions, dementia, or personality disorder
• Plans to leave area within 6 months
• Refuses informed consent
• Failure to pass screening test:pulmonary function, echocardiogram,or exercise

Where it is running

• Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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