Induction of Labor With Oxytocin: When Should Oxytocin be Held?

Completed · Not applicable

Conditions studied: Labor Induction, Cesarean Delivery

In brief

The investigators propose to perform a prospective randomized control trial to compare the rate of cesarean delivery in women where Oxytocin (OT) is discontinued once active labor begins (5 cm dilation) when compared with women where OT is continued at a maintenance level per the usual protocol. One study group will follow an oxytocin protocol which is incremental until 5 cm dilation and then maintained at the same level throughout labor. The second arm will follow an oxytocin protocol also incremental, but then discontinued once the cervix is 5 cm. The primary outcome will be the rate of cesarean delivery between the groups. Secondary outcomes to be evaluated will include duration of the labor, fetal heart rate abnormalities, and frequency of uterine hyperstimulation, maternal and neonatal outcomes. As mentioned in the study proposal, the proposed experimental arm is currently not performed as part of the oxytocin guidelines at the investigators' institution. One study from Israel suggests no difference in pregnancy outcomes with the proposed use of oxytocin. Although some providers stop the oxytocin in active labor for their patients, this is not a commonly performed procedure at the investigators' institution. The investigators are not aware of other institutions employing the above practice.

Key facts

Study ID

NCT00957593

Run by

Lehigh Valley Hospital

People needed

252

Starts

2009-02-01

Expected to finish

2011-08-01

Last updated by the study team

2019-04-23

Who can join

Age: 18 and older, up to 50. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Candidates for the study are pregnant women (with one fetus) scheduled for induction of labor with oxytocin at term gestation or greater, regardless of the indication for induction, bishop score (cervical dilation) or parity.

You may not qualify if…

• Exclusions include women with multiple gestations, previous cesarean sections, and documented fetal anomalies.
• Women with contraindications to labor or induction will also be excluded.

Where it is running

• Lehigh Valley Health Network — Allentown, Pennsylvania, United States

Full record on ClinicalTrials.gov

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