RT With or Without Cetuximab in Treating Patients Who Have Undergone Surgery for Locally Advanced Head and Neck Cancer
Running, not enrolling · Phase 3
Conditions studied: Head and Neck Cancer
In brief
RATIONALE: Giving radiation therapy that uses a 3-dimensional (3-D) image of the tumor to help focus thin beams of radiation directly on the tumor, and giving radiation therapy in higher doses over a shorter period of time, may kill more tumor cells and have fewer side effects. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether radiation therapy is more effective when given alone or together with cetuximab in treating patients with head and neck cancer that has been removed by surgery. PURPOSE: This randomized phase III trial is studying radiation therapy to see how well it works compared with radiation therapy given together with cetuximab in treating patients who have undergone surgery for locally advanced head and neck cancer.
Key facts
- Study ID
- NCT00956007
- Run by
- Radiation Therapy Oncology Group
- People needed
- 702
- Starts
- 2010-03-31
- Expected to finish
- 2029-08-01
- Last updated by the study team
- 2026-01-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Arizona Oncology Associates-West Orange Grove — Tucson, Arizona, United States
- Sutter Cancer Centers Radiation Oncology Services-Auburn — Auburn, California, United States
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park — Cameron Park, California, United States
- Mercy San Juan Medical Center — Carmichael, California, United States
- City of Hope — Duarte, California, United States
- UC San Diego Moores Cancer Center — La Jolla, California, United States
- Kaiser Permanente Los Angeles Medical Center — Los Angeles, California, United States
- Los Angeles County-USC Medical Center — Los Angeles, California, United States
- University of Southern California/Norris Cancer Center — Los Angeles, California, United States
- Memorial Medical Center — Modesto, California, United States
- Bay Area Tumor Institute CCOP — Oakland, California, United States
- Pomona Valley Hospital Medical Center — Pomona, California, United States
- Sutter Cancer Centers Radiation Oncology Services-Roseville — Roseville, California, United States
- The Permanente Medical Group-Roseville Radiation Oncology — Roseville, California, United States
- Sutter General Hospital — Sacramento, California, United States
- University of California at Davis Cancer Center — Sacramento, California, United States
- Mercy General Hospital Radiation Oncology Center — Sacramento, California, United States
- UCSF-Mount Zion — San Francisco, California, United States
- Kaiser Permanente Medical Center - Santa Clara — Santa Clara, California, United States
- Saint Helena Hospital — St. Helena, California, United States
- Stanford University Hospitals and Clinics — Stanford, California, United States
- Sutter Cancer Centers Radiation Oncology Services-Vacaville — Vacaville, California, United States
- Rocky Mountain Cancer Centers-Aurora — Aurora, Colorado, United States
- University of Colorado Cancer Center - Anschutz Cancer Pavilion — Aurora, Colorado, United States
- University of Alabama at Birmingham — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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