Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Apathy in Parkinson's Disease
Completed · Not applicable · Has a placebo group
Conditions studied: Parkinson's Disease
In brief
The purpose of this research study is to attempt to treat apathy in Parkinson's disease (PD) using high-frequency repetitive transcranial magnetic stimulation (rTMS) of the brain and to investigate the patterns of brain activation that may be involved in apathy. It is hypothesized that high-frequency rTMS of the left mid-dorsolateral frontal cortex will improve apathy in PD.
Key facts
- Study ID
- NCT00955032
- Run by
- University of Florida
- People needed
- 24
- Starts
- 2007-04-01
- Expected to finish
- 2009-12-01
- Last updated by the study team
- 2013-04-26
Who can join
Age: 30 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- diagnosis of "probable" PD, defined by the presence of at least 2 out of 3 cardinal motor features of PD (resting tremor, rigidity, and bradykinesia, plus a sustained and significant response to dopaminergic treatment);
- age 30 or over; and
- on stable medications for at least 30 days.
You may not qualify if…
- features suggestive of other causes of parkinsonism/ parkinson-plus syndromes;
- history of deep brain stimulation or ablation surgery, significant headaches, epilepsy or seizure disorder, mass brain lesions, or major head trauma leading to loss of consciousness of any length;
- family (1st degree relatives) history of epilepsy;
- evidence for dementia;
- presence of contraindications for functional magnetic resonance imaging (fMRI);
- history of schizophrenia, schizoaffective disorder, other psychosis, rapid-cycling bipolar illness, alcohol/drug abuse within the past year;
- need for rapid clinical response due to conditions such as initiation, psychosis, or suicidality;
- unstable medical condition such as diabetes, cardiac disease, hypertension;
- pregnancy; and
- colorblindness.
Where it is running
- University of Florida — Gainesville, Florida, United States
Full record on ClinicalTrials.gov
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