Observational Study of Iron Overload in Stem Cell Transplantation
Completed
Conditions studied: Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome
In brief
Recent retrospective studies have suggested that iron overload is a clinically important problem in patients undergoing ablative stem cell transplantation. However, these studies relied on serum ferritin as a surrogate of iron overload, which limits the conclusions that can be drawn from such analyses. Therefore, the investigators are conducting a prospective study to more rigorously examine the prevalence, mechanisms, and consequences of iron overload in this patient population.
Key facts
- Study ID
- NCT00954720
- Run by
- Dana-Farber Cancer Institute
- People needed
- 45
- Starts
- 2008-03-01
- Expected to finish
- 2011-05-01
- Last updated by the study team
- 2013-02-28
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years.
- Histologically confirmed acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), or myelodysplastic syndrome (MDS)
- Planned allogeneic stem cell transplantation with myeloablative conditioning regimen (regardless of stem cell source or donor HLA match)
- Patients will be eligible even if they have had prior stem cell transplantation (autologous or allogeneic)
You may not qualify if…
- Contraindication to magnetic resonance imaging (MRI):
- Patients with cardiac pacemakers, implanted cardiac defibrillator (ICD), cardiac electrodes, pacing wires, internal electrodes, cochlear, otologic or other ear implants, metallic fragments or foreign body, metallic prosthesis. Patients with surgical staples should not be imaged until 7 days post-op unless approved by a radiologist;
- Severe claustrophobia
- Note: a history of allergic reaction to gadolinium is not a contraindication to enrollment, as contrast will not be used.
- Inability to provide informed consent
Where it is running
- Dana Farber Cancer Institute — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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