Study of Left Ventricular Dyssynchrony in Heart Failure Patients
Completed
Conditions studied: Heart Failure
In brief
Heart failure has become one of the major epidemics of the modern era. Despite optimal standard drug therapy, the prognosis of patients with heart failure remains poor. Patient with Heart Failure are prone to have "dyssynchrony" which means that there are electrical disturbances that cause the heart to pump blood in an inefficient way. Ventricular dyssynchrony has been associated with increased mortality in patients with heart failure. Based on these observations, techniques have been developed to correct dyssynchrony. The investigators propose to investigate the change of dyssynchrony in relation to intravascular volume status and exercise in heart failure patients. The investigators also propose to examine dyssynchrony in the setting of acutely decompensated heart failure. The change in dyssynchrony will be followed to examine if it translates into clinical significance.
Key facts
- Study ID
- NCT00953953
- Run by
- Albert Einstein Healthcare Network
- People needed
- 16
- Starts
- 2007-01-01
- Expected to finish
- 2011-10-01
- Last updated by the study team
- 2012-01-26
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients over the age of 18 and able to consent
- NYHA Class III or IV
- EF≤ 35%
- Diagnosis of acute congestive heart failure exacerbation by history or physical examination
- Ability to understand and willing to sign informed consent
- Willingness to follow-up for clinic visits at 30 days and 6 months
You may not qualify if…
- Pacemaker
- Patients requiring and willing to sign informed consent
- Unwillingness to provide consent
- CHRONIC HEART FAILURE on DIALYSIS GROUP
- Inclusion Criteria:
- Patients over the age of 18 and able to consent
- NYHA Class II, III, or IV
- EF ≤ 35% with a screening echocardiogram
- Ability to understand and willing to sign informed consent
- Willingness to follow up at 30 days and 6 months via phone contact
- Exclusion Criteria:
- Unwillingness to provide consent
- Pacemaker
- AMBULATORY CHRONIC HEART FAILURE GROUP
- Inclusion Criteria:
- Patients over the age of 18 and able to consent
- NYHA Class II and III with an EF ≤ 35%
- Diagnosis of chronic heart failure and currently on optimal medical therapy, including ACE, or ARB, beta-blockers and diuretics including spironolactone
- Ability to understand and willing to sign informed consent
- Willingness to follow up as an outpatient at 30 days and 6 months
- Exclusion Criteria:
- Incapable of taking the 6-minute walk test due to any condition unrelated to heart failure
- Patients requiring chronic inotrope therapy
- Pacemaker
- Symptoms of angina limiting exercise ability
Where it is running
- Albert Einstein Medical Center — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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