Thalidomide for the Treatment of Primary Sclerosing Cholangitis (PSC)

Stopped early · Phase 2

Conditions studied: Primary Sclerosing Cholangitis

In brief

The purpose of this study is to determine the safety and benefit of Thalidomide with primary sclerosing cholangitis (PSC). This is a six month study.

Key facts

Study ID

NCT00953615

Run by

Mayo Clinic

People needed

1

Starts

2006-04-01

Expected to finish

2009-05-01

Last updated by the study team

2012-02-27

Who can join

Age: 18 and older, up to 72. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Previous diagnosis of primary sclerosing cholangitis as defined by: serum alkaline phosphatase level greater than or equal to 1.5 times the upper limit of normal, negative serum antimitochondrial antibody test, cholangiography diagnostic of PSC without other etiology for biliary obstruction, and liver histology consistent with or diagnostic of PSC
• Patients must give written informed consent.
• Patients must be willing and able to comply with the most recent version of the FDA-mandated System for Thalidomide Education and Prescribing Safety (S.T.E.P.S.®) program.

You may not qualify if…

• Pregnant and/or lactating female
• Inability or unwillingness to practice contraceptive measures for the prevention of pregnancy
• History of hypersensitivity reaction to thalidomide
• Inability to provide consent
• Findings suggestive of liver disease of other etiology such as primary biliary cirrhosis, chronic alcoholic liver disease, chronic hepatitis B and C infection, hemochromatosis, Wilson's disease, alpha-1-antitrypsin deficiency, autoimmune hepatitis, and cryptogenic liver disease
• Anticipated need for liver transplantation in one year from decompensated chronic liver disease or recurrent variceal bleeding, spontaneous hepatic encephalopathy, or refractory ascites
• Treatment with tacrolimus, cyclosporine, sirolimus, ursodeoxycholic acid, corticosteroids, colchicine, methotrexate, azathioprine, cyclosporine, chlorambucil, budesonide, pentoxifylline, nicotine, silymarin, vitamin E or pirfenidone in the preceding three months
• History of peripheral neuropathy
• Use of medications with significant drug-drug interactions with thalidomide
• History of Human Immunodeficiency Virus (HIV) positive status or Acquired Immunodeficiency Syndrome (AIDS)
• History of coexistent advanced malignancy
• History of coexistent severe cardiovascular disease
• History of coexistent severe renal disease
• History of current excessive or recent (within 6 months) alcohol use
• Any condition that, in the opinion of the investigators, would interfere with the patient's ability to complete the study safely or successfully
• History of thrombolytic events. Combination use with corticosteroids increases risk of deep vein thrombosis.

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.