Study of Tumor Samples in Patients Undergoing Radiation Therapy or Surgery For Primary Melanoma of the Eye

Completed

Conditions studied: Intraocular Melanoma

In brief

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This clinical trial is studying tumor samples in patients undergoing surgery or radiation therapy for primary melanoma of the eye.

Key facts

Study ID

NCT00952939

Run by

Case Comprehensive Cancer Center

People needed

150

Starts

2009-03-01

Expected to finish

2014-02-01

Last updated by the study team

2015-01-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must have a clinical diagnosis of melanoma of the iris, ciliary body and/or choroids
• Patients must have had a hepatic ultrasound and/or other suitable imaging studies to eliminate metastatic disease
• Patients must not have received any local or systemic therapy for uveal melanoma
• All patients must be informed of the investigational nature of this study and must provide written informed consent in accordance with institutional and federal guidelines. A copy of the informed consent document signed by the patient must be given to the patient
• Patients must have the following pretreatment laboratory findings:
• Bilirubin (total) </= 1.5 ml/dl
• AST </= 2 x normal
• ALT </= 2 x normal
• Alkaline phosphatase </= 2 x normal

You may not qualify if…

• Patients with metastasis
• Patients under the age of 18

Where it is running

• Cleveland Clinic Cole Eye Institute — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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