Preventing Acute Chest Syndrome by Transfusion Feasibility Study

Completed · Not applicable

Conditions studied: Sickle Cell Disease

In brief

Acute chest syndrome (ACS) is similar to severe pneumonia and is a common cause of hospitalizations for people with sickle cell disease (SCD). Blood transfusions are one treatment option for ACS. High levels of an enzyme called secretory phospholipase A2 (sPLA2) may be present in people before they develop ACS. This study will determine how well sPLA2 levels can predict the onset of ACS and whether identifying high sPLA2 levels allows enough time to prevent ACS with blood transfusions. Results from this study will help to determine the feasibility of conducting a larger study that would further examine the use of sPLA2 levels and blood transfusions to prevent ACS in people with SCD.

Key facts

Study ID

NCT00951808

Run by

Carelon Research

People needed

237

Starts

2009-07-01

Expected to finish

2010-07-01

Last updated by the study team

2013-04-24

Who can join

Age: 2 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Children's Hospital and Research Center — Oakland, California, United States
• A.I. duPont Hospital for Children — Wilmington, Delaware, United States
• Children's National Medical Center — Washington D.C., District of Columbia, United States
• Howard University Hospital — Washington D.C., District of Columbia, United States
• Emory University School of Medicine — Atlanta, Georgia, United States
• Medical College of Georgia — Augusta, Georgia, United States
• Children's Memorial Hospital — Chicago, Illinois, United States
• University of Illinois Sickle Cell Center — Chicago, Illinois, United States
• Kosair Children's Hospital — Louisville, Kentucky, United States
• Johns Hopkins — Baltimore, Maryland, United States
• Boston Medical Center — Boston, Massachusetts, United States
• Brigham & Women's Hospital — Boston, Massachusetts, United States
• Children's Hospital Boston — Boston, Massachusetts, United States
• University of Mississippi Medical Center — Jackson, Mississippi, United States
• Interfaith Medical Center — Brooklyn, New York, United States
• New York Methodist Hospital — Brooklyn, New York, United States
• The University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States
• Duke University Medical Center — Durham, North Carolina, United States
• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
• Nationwide Children's Hospital — Columbus, Ohio, United States
• Ohio State University — Columbus, Ohio, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• St. Christopher's Hospital for Children — Philadelphia, Pennsylvania, United States
• Virginia Commonwealth University Health Systems — Richmond, Virginia, United States

Full record on ClinicalTrials.gov

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