Optical Defocus to Stimulate Eye Elongation in Hyperopia

Status unconfirmed · Not applicable

Conditions studied: Hyperopia, Refractive Error

In brief

Axial hyperopia results when the length of the eye is too short for the eye to properly focus distance objects on the retina while the focusing system is relaxed. Emmetropization is the process by which the eye actively adjusts various components of the eye to gradually improve the focus of the eye. Emmetropization frequently involves either an increase or a decrease in the growth of the eye, particularly during infancy and childhood. Numerous animal studies suggest that if an animal is exposed to retinal images located behind the retina either centrally or peripherally, the eye will grow in the direction of the focused image. If an abnormally short eye has resulted in hyperopia, exposing such an eye to retinal images partially located behind the retina might encourage axial elongation, thus reducing the hyperopia.

Key facts

Study ID

NCT00950924

Run by

Aller, Thomas A., OD

People needed

30

Starts

2015-01-01

Expected to finish

2022-01-01

Last updated by the study team

2021-01-12

Who can join

Age: 5 and older, up to 12. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Aged 5-12
• Hyperopia > +1.25 each eye (cycloplegic refraction)
• Ability to wear soft contact lenses

You may not qualify if…

• Amblyopia
• Strabismus
• Astigmatism > 1.00 diopters
• Axial Length > 24.00 mm

Where it is running

• 711 Kains Ave — San Bruno, California, United States

Full record on ClinicalTrials.gov

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